K.N.O.W. Home Health - IMMUNOSUPPRESSANT

Immunosuppressants (e.g., Tacrolimus, Cyclosporine, Azathioprine, Prednisone).

High-Risk Concerns with Immunosuppressants:

· High Risk: Increased risk of infections, nephrotoxicity (Kidney), hepatotoxicity (Liver).

General Guidance:

• Do not ignore any unusual symptoms.

• Mild symptoms should be reported to your home health agency.

• Severe symptoms require emergency medical attention.

Call Your Home Health Agency Immediately if You Experience:

· Mild fever (below 100.4°F or 38°C) without other signs of infection

· Increased fatigue or weakness beyond usual levels

· Mild nausea, vomiting, or diarrhea that is persistent but manageable

· Tremors (shakiness) or mild headaches

· Mild swelling in the hands or feet

· Increased blood pressure that is above normal but not dangerously high

· Gum overgrowth or changes in the mouth (common with Cyclosporine)

· Mild mood changes, anxiety, or insomnia (common with Prednisone)

· Slow-healing wounds or easy bruising

Go to the Emergency Room (or Call 911) If You Have:

· Fever of 100.4°F (38°C) or higher (possible infection, which can be life-threatening due to immunosuppression)

· Severe headache, confusion, or vision changes (possible high blood pressure crisis or neurological issue)

· Severe chest pain, shortness of breath, or irregular heartbeat (possible cardiovascular complications)

· Uncontrolled nausea, vomiting, or diarrhea leading to dehydration

· Severe swelling, rapid weight gain, or decreased urine output (possible kidney dysfunction)

· Signs of organ rejection (pain around the transplant site, flu-like symptoms, sudden swelling)

· Severe muscle weakness or tingling/numbness (possible neurotoxicity)

· Seizures (possible Tacrolimus or Cyclosporine toxicity)

· Severe mood changes, hallucinations, or suicidal thoughts (possible steroid-induced psychosis)

· Jaundice (yellowing of skin/eyes), dark urine, or severe abdominal pain (possible liver toxicity)

· Uncontrollable bleeding or bruising

Because immunosuppressants weaken the immune system, infections and complications can escalate quickly. If any symptoms seem severe, rapidly worsening, or involve vital functions, go to the ER immediately. If symptoms are concerning but stable, notify the Home Health Agency for further assessment.